Our preliminary research efforts include understanding the role of inflammation, preexisting genetic risk factors and the identification of combinatorial gene-protein signatures that are indicative of disease type or progression. These multiple parallel analysis workstreams include longitudinal profiling, cross-sectional profiling, proteogenomic analysis and multivariate prediction. Within each workstream, consortium members may pursue any number of specific projects and collaborate with each other to combine expertise.
The size and diversity of the HDS allows for each research question raised within a workstream to be applied broadly across the field of neurodegenerative disorders or to a specific disease area.
The HDS includes over 40,000 samples for diseases that include Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).